{"id":146,"date":"2024-06-08T12:00:57","date_gmt":"2024-06-08T12:00:57","guid":{"rendered":"https:\/\/dev.campbellneurosciences.com\/?page_id=146"},"modified":"2024-06-08T12:00:58","modified_gmt":"2024-06-08T12:00:58","slug":"suicide-a-sad-state-of-affairs","status":"publish","type":"page","link":"https:\/\/campbellneurosciences.com\/index.php\/suicide-a-sad-state-of-affairs\/","title":{"rendered":"Suicide: A sad state of affairs"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|tablet&#8221; next_background_color=&#8221;#ffffff&#8221; admin_label=&#8221;Hero&#8221; _builder_version=&#8221;4.24.3&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_type=&#8221;circular&#8221; background_color_gradient_direction_radial=&#8221;top right&#8221; background_color_gradient_stops=&#8221;rgba(255,255,255,0) 20%|rgba(1,77,183,0.9) 100%&#8221; background_color_gradient_overlays_image=&#8221;on&#8221; background_color_gradient_start=&#8221;rgba(255,255,255,0)&#8221; 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header_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;]<\/p>\n<h1><span style=\"font-size: xx-large;\">Campbell Neurosciences, inc.<\/span><\/h1>\n<p><span style=\"font-size: x-large;\">Committed to establishing a biological basis for diagnosis and treatment of suicide and its causes, including Schizophrenia and other mental health disorders, thereby eliminating the stigma of the disease.<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221; theme_builder_area=&#8221;post_content&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_row _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-31px|auto||auto||&#8221; custom_padding=&#8221;0px|||||&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_text _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><strong class=\"text-strong\">Suicide: A Sad State of Affairs<\/strong><\/p>\n<ul>\n<li>Suicide is the second largest killer of young people, the 10th cause of death for all age groups<\/li>\n<\/ul>\n<ul>\n<li>Worldwide, one suicide occurs every 40 seconds globally<\/li>\n<\/ul>\n<ul>\n<li>Current interventions are just \u201cband-aids\u201d<\/li>\n<\/ul>\n<ul>\n<li>30% increase in suicide in the last 20 years<\/li>\n<\/ul>\n<ul>\n<li>Psychiatry is the only discipline of medicine that does not have a biological basis<\/li>\n<\/ul>\n<ul>\n<li>Stigma has prevented significant research<\/li>\n<\/ul>\n<p><strong class=\"text-strong\">The Immune System is Part of the Brain<\/strong><\/p>\n<ul>\n<li>The nervous and immune systems are interconnected<\/li>\n<\/ul>\n<ul>\n<li>Many studies show that the brain controls immune function<\/li>\n<\/ul>\n<ul>\n<li>The Pavlov study is an example of how the brain can be taught to control immune function<\/li>\n<\/ul>\n<ul>\n<li>If specific nerves from the brain are severed, the immune function increases or decreases depending on the nerve<\/li>\n<\/ul>\n<ul>\n<li>All major immune organs are innervated<\/li>\n<\/ul>\n<ul>\n<li>It is impractical to access the brain to quantitatively assess suicidal thoughts<\/li>\n<\/ul>\n<ul>\n<li>The<span>\u00a0<\/span><span class=\"posthilit\">Campbell<\/span><span>\u00a0<\/span>Score is based on using immune markers to understand what is going on in the brain<\/li>\n<\/ul>\n<p><strong class=\"text-strong\">Evidence that Immune System Can Cause Suicide<\/strong><\/p>\n<ul>\n<li>Interferon alpha is an immune stimulant used for leukemia and hepatitis C<\/li>\n<\/ul>\n<ul>\n<li>Interferon alpha activates IL-6 and microglia<\/li>\n<\/ul>\n<ul>\n<li>Chronic activation of microglia causes brain damage<\/li>\n<\/ul>\n<ul>\n<li>Microglia enzyme indolamine 2,3 deoxygenase reduces tryptophan and generates kynurenine, which is a depressive molecule<\/li>\n<\/ul>\n<ul>\n<li>Associations between interferon administration and suicide<\/li>\n<\/ul>\n<ul>\n<li>Associations between numerous other cancer immunotherapies and suicide<\/li>\n<\/ul>\n<p><strong class=\"text-strong\">Interleukin 6 as a Marker of Suicidal Ideations<\/strong><\/p>\n<ul>\n<li>Up-regulated in plasma of patients suffering from causes of suicide<\/li>\n<\/ul>\n<ul>\n<li>MDD, Schizophrenia, PTSD<\/li>\n<\/ul>\n<ul>\n<li>Up-regulated in plasma of suicidal patients<\/li>\n<\/ul>\n<ul>\n<li>Found in brain biopsy of suicide victims<\/li>\n<\/ul>\n<ul>\n<li>Can be altered based on successful therapy<\/li>\n<\/ul>\n<ul>\n<li>Can be altered by anti-inflammatory drugs or psychotherapy<\/li>\n<\/ul>\n<p><strong class=\"text-strong\">Patients who Commit Suicide have Higher Levels of Inflammatory Cytokines<\/strong><\/p>\n<p><strong class=\"text-strong\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/campbellneurosciences.com\/wp-content\/uploads\/2024\/06\/sui1-1024x730.png\" width=\"1024\" height=\"730\" alt=\"\" class=\"wp-image-149 alignnone size-large\" srcset=\"https:\/\/campbellneurosciences.com\/wp-content\/uploads\/2024\/06\/sui1-980x698.png 980w, https:\/\/campbellneurosciences.com\/wp-content\/uploads\/2024\/06\/sui1-480x342.png 480w\" sizes=\"auto, (min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1024px, 100vw\" \/><\/strong><\/p>\n<p><strong class=\"text-strong\">Elevation of IL-6 in MDD Patients<\/strong><\/p>\n<p><strong class=\"text-strong\"><span>Findings:<\/span><br \/><\/strong>In this graph, blood was taken from healthy controls (HC) and patients with Major Depressive Disorder (MDD). Levels of IL-6 were measured. On average patients with depression had more IL-6<br \/><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6414189\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6414189\/<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/campbellneurosciences.com\/wp-content\/uploads\/2024\/06\/sui2-1024x730.png\" width=\"1024\" height=\"730\" alt=\"\" class=\"wp-image-150 alignnone size-large\" srcset=\"https:\/\/campbellneurosciences.com\/wp-content\/uploads\/2024\/06\/sui2-980x698.png 980w, https:\/\/campbellneurosciences.com\/wp-content\/uploads\/2024\/06\/sui2-480x342.png 480w\" sizes=\"auto, (min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1024px, 100vw\" \/><\/p>\n<p><strong class=\"text-strong\">Elevation of IL-6 in PTSD<\/strong><\/p>\n<p><b>Findings:<\/b><br \/>Blood was taken from healthy controls and PTSD patients. IL-6 was measured in unstimulated and stimulated (LPS) blood. IL-6 was higher in PTSD patients regardless of stimulation.<br \/><a href=\"https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/10.1186\/1471-244X-13-40\/figures\/1\">https:\/\/bmcpsychiatry.biomedcentral.com\/articles\/10.1186\/1471-244X-13-40\/figures\/1<\/a>\u00a0<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/campbellneurosciences.com\/wp-content\/uploads\/2024\/06\/sui3-1024x730.png\" width=\"1024\" height=\"730\" alt=\"\" class=\"wp-image-151 alignnone size-large\" srcset=\"https:\/\/campbellneurosciences.com\/wp-content\/uploads\/2024\/06\/sui3-980x698.png 980w, https:\/\/campbellneurosciences.com\/wp-content\/uploads\/2024\/06\/sui3-480x342.png 480w\" sizes=\"auto, (min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1024px, 100vw\" \/><\/p>\n<p><strong class=\"text-strong\">Elevation of IL-6 in Schizophrenia<\/strong><\/p>\n<p><span><b>Findings:<\/b><\/span><br \/><span>Blood was taken from patients with schizophrenia before and after treatment with mood stabilizing drugs and after as well from healthy controls. IL-6 was highest before treatment and was significantly reduced after treatment. Healthy controls had the lowest IL-6.<br \/><a href=\"https:\/\/www.researchgate.net\/figure\/Serum-concentrations-of-IL-1b-IL-6-and-TNF-a-in-schizophrenia-patients-after-treatment_fig1_333968438\">https:\/\/www.researchgate.net\/figure\/Serum-concentrations-of-IL-1b-IL-6-and-TNF-a-in-schizophrenia-patients-after-treatment_fig1_333968438<\/a><\/span><\/p>\n<p><span><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/campbellneurosciences.com\/wp-content\/uploads\/2024\/06\/sui4-1024x730.png\" width=\"1024\" height=\"730\" alt=\"\" class=\"wp-image-152 alignnone size-large\" srcset=\"https:\/\/campbellneurosciences.com\/wp-content\/uploads\/2024\/06\/sui4-980x698.png 980w, https:\/\/campbellneurosciences.com\/wp-content\/uploads\/2024\/06\/sui4-480x342.png 480w\" sizes=\"auto, (min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1024px, 100vw\" \/><\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Campbell Neurosciences, inc. Committed to establishing a biological basis for diagnosis and treatment of suicide and its causes, including Schizophrenia and other mental health disorders, thereby eliminating the stigma of the disease.Suicide: A Sad State of Affairs Suicide is the second largest killer of young people, the 10th cause of death for all age groups [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-146","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/campbellneurosciences.com\/index.php\/wp-json\/wp\/v2\/pages\/146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/campbellneurosciences.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/campbellneurosciences.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/campbellneurosciences.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/campbellneurosciences.com\/index.php\/wp-json\/wp\/v2\/comments?post=146"}],"version-history":[{"count":2,"href":"https:\/\/campbellneurosciences.com\/index.php\/wp-json\/wp\/v2\/pages\/146\/revisions"}],"predecessor-version":[{"id":153,"href":"https:\/\/campbellneurosciences.com\/index.php\/wp-json\/wp\/v2\/pages\/146\/revisions\/153"}],"wp:attachment":[{"href":"https:\/\/campbellneurosciences.com\/index.php\/wp-json\/wp\/v2\/media?parent=146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}